Anavar Oxandrolone OXA


Pharmaceutical Name: Oxandrolone (OXA)

Chemical Structure: 5 alpha-androstan-2-oxa-17
alpha-methyl-17 beta-ol-3-one

Molecular Weight Of Base: 306.4442

Effective Dose: 20-40 mg/day for men, 10-15 mg/day for
women

Average Street-Price: $300-500 for 10 tabs

Available Doses: 0.5, 2, 2.5 and 5mg tabs

An
intrinsically weak steroid with a high price-tag and low availability,
oxandrolone owes its large popularity due to its safety. In sharp contrast to
oxymetholone, oxandrolone is quite generally considered to be the safest of all
steroids. Its effects are more than well-documented and have been for a few
decades now. The medical community values oxandrolone as a safe alternative for
more harmful steroids, which is why it is considered safe for use in children
and even in patients suffering hepa-toxicity as the result of alternate steroid
use1.

It’s most noted medical use has been in the expediting of wound healing2,3
often practically applied to the treatment of burns 4,5,6. But recently its
gaining popularity again as a means of keeping weight on HIV-infected patients
suffering from wasting due to the immuno-deficiency virus. It was also
considered safe for use in prepubescent children with a growth delay7. No major
harmful effects were noted from this particular therapy, eventhough one study8
reported that the use of oxandrolone did speed up the onset of puberty in these
children. Furthermore oxandrolone has found frequent applications in the
treatment of other wasting symptoms for hepatitis and cancer as well as the
treatment of osteoporosis in both men and women of all ages.

Oxandrolone was introduced in the year 1964, when Searle came out with the
original Anavar. It quickly became the popular drug in the sports crowd for
people looking for a safer alternative to the major steroid at the time,
Dianabol (methandrostenolone). It remained one of the best-sellers for well
over 2 decades until it was indefinitely discontinued in the year 1989. Much to
the regret of the recreational bodybuilding and powerlifting community. The
prices have remained high for the little stock that remained available. The
only brand readily found was oxandrolone SPA, manufactured in Milano, Italy.
That is, until 1995 when its use in the treatment of the then vastly spreading
immuno-deficiency disease AIDS9 sparked the interest of BTG, a US-based company
who came out with Oxandrin. The first widely available oxandrolone product
since Anavar production was stopped.

The main reasons for the wide-spread use of oxandrolone in sports is because it
is very appealing to female athletes as well as male athletes. It causes little
or no virilization properties, demonstrated by its medical uses to treat women.
This is rather surprising since oxandrolone does not aromatize either. It’s the
only steroid that is both safe and convenient without producing excess
estrogen. That makes it particularly useful when cutting up for a contest or
preventing an increase in body-fat due to estrogenic effects. In fact the main
use of oxandrolone to a bodybuilder is in the maintenance of lean mass while
reducing body-fat. Oxandrolone itself may not actually reduce body-fat, but it
too plays a key role in the process. Like most non-aromatizing compounds it has
a repressing effect on the appetite making it easier for the user to control
cravings and stay strict with his diet.

Oxandrolone also has little effect on the body’s own natural hormone
production. The negative feedback was found to be very minor, meaning that
during short term use no suppression of Gonadotropin releasing hormone (GnRH,
start of natural testosterone production) was noted. This meant that whatever
gains made, as little as they may have been, were very easily maintained
post-cycle. So there was also no use for products like Clomid or Nolvadex in
conjunction with oxandrolone consumption. The easy to maintain low gains would
indicate a low binding to the androgen receptor. While not extremely high, it
should actually be noted that it does have quite decent binding to the androgen
receptor. But the reason for its mild effects is quite likely the low dose
used. Rarely if ever are doses higher than 20 mg used on a daily basis. Either
because of convenience or due to the high price. But comparing that the doses
of other steroids this is remarkably low. So its only logical the gains and
side-effects aren’t particularly notable.

Of course a bodybuilder has limited use for a compound that is both a weak
androgen in the doses mostly used and doesn’t aromatize since no mentionable effect
on mass can be produced to satisfy the chemically enhanced athlete. Therefor it
is best noted that oxandrolone is most popular with power- and weightlifters to
enhance strength without increasing bodyweight. This is valued highly since
strength athletes often compete in weight-classes. Oxandrolone does not
increase strength through androgenic stimulation, at least not primarily. It
stimulates the formation of phosphocreatine, a body compound that can replenish
ATP (adenosine tri-phosphate) , the main energy currency of the living
organism. This gives an incredible increase in short term anaerobic
performance, the type needed for explosive action such as sprinting and lifting
weight.

For bodybuilders the best results are seen when stacking oxandrolone with a
highly androgenic compound. Either during a mass stack with aromatizable
products to boost strength a little more, or in conjunction with a
non-estrogenic compound. This is most beneficial since it can maintain lean
mass, decrease appetite, improve sharpness of the muscle and keep strength
levels up without giving increased androgenic risk (acne, prostate hypertrophy,
hair loss) when stacked with pure androgens (stanozolol, drostanolone). For
those looking for safe maintenance of muscle mass a stack of Anavar with
Primobolan is not a bad investment (but a big investment). The common use of
oxandrolone is estimated, at 0.125 mg per pound of bodyweight. For men it
should be closer to 0.2 mg per pound, for women 0.08 mg per pound per day.

The downsides to oxandrolone are minor. The worst problem by far is the poor
availability and high price. But it has to be noted that, eventhough
oxandrolone is nowhere near Halotestin or anadrol in hepa-toxicity, it too is a
17-alpha-alkylated substance that can cause liver damage if used for long
periods on end. Other common side-effects include headaches, loss of libido,
diarrhea and dizziness.

The conclusion to follow these paragraphs is of course that oxandrolone is
understandably still a popular and very versatile steroid, much desired by both
experienced athletes and novice users because of its many properties. While few
will say this is the best or their favorite steroid, you won’t find many that
will have anything negative to say about it either.

Stacking and Use:

Because of its mild nature and the low doses generally used with oxandrolone
there is very little use for secondary compounds like anti-aromatase drugs,
estrogen receptor antagonists or blood pressure medication. That in itself may
somewhat make up for the high cost and little gains made on it.

In stacks Anavar is sometimes used to increase strength or help maintain it
during mass phases. Oxandrolone obviously has very little to add in terms of
mass compared to the other substances used to obtain such goals. It fades in
comparison to test, Deca, Anadrol, D-bol and such. Nonetheless it is added
quite often, perhaps because people assume it will make the overall stack less
hazardous, but that’s a myth of course. Frankly I would imagine there are better
and cheaper things to waste your money on if mass is what you seek.

On a cutting phase oxandrolone makes a good match for 120-140 mcg of
clenbuterol daily stacked with something in the nature of Halotestin or
Winstrol. The combination improves muscle hardness and striation as well as
support mass and strength retention. Experienced users would preferably add
testosterone propionate or Equipoise no doubt, rather than Halotestin or
Winstrol due to less hazard to the liver associated with those two drugs,
especially Halotestin.

Mostly it is used for decent strength gains without gaining too much weight,
particularly suited for weight- and powerlifters and martial artists. In that
aspect, and in my humble opinion, Winstrol would be a good choice for a stack.
50 mg of Winstrol every day to every other day stacked with 30-40 mg of
oxandrolone daily would give a very good result in overall strength enhancement
without adding a mentionable amount of weight to the frame.

References

1 Segal S, Cooper J, Bolognia J., Treatment of lipodermatosclerosis with
oxandrolone in a patient with stanozolol-induced hepatotoxicity., J Am Acad
Dermatol 2000 Sep;43(3):558-9

2 Demling RH., Oxandrolone, an anabolic steroid, enhances the healing of a
cutaneous wound in the rat., Wound Repair Regen 2000 Mar-Apr;8(2):97-102

3 Demling RH, Orgill DP., The anticatabolic and wound healing effects of the
testosterone analog oxandrolone after severe burn injury., J Crit Care 2000
Mar;15(1):12-7

4 Hart DW, Wolf SE, Ramzy PI, Chinkes DL, Beauford RB, Ferrando AA, Wolfe RR,
Herndon DN., Anabolic effects of oxandrolone after severe burn., Ann Surg 2001
Apr;233(4):556-64

5 Demling RH, DeSanti L., The rate of restoration of body weight after burn
injury, using the anabolic agent oxandrolone, is not age dependent., Burns 2001
Feb;27(1):46-51

6 Demling RH, DeSanti L., Oxandrolone, an anabolic steroid, significantly
increases the rate of weight gain in the recovery phase after major burns., J
Trauma 1997 Jul;43(1):47-51

7 Papadimitriou A, Preece MA, Rolland-Cachera MF, Stanhope R., The anabolic
steroid oxandrolone increases muscle mass in prepubertal boys with
constitutional delay of growth., J Pediatr Endocrinol Metab 2001
Jun;14(6):725-7

8 Doeker B, Muller-Michaels J, Andler W, Induction of early puberty in a boy
after treatment with oxandrolone? Horm Res 1998;50(1):46-8

9 James JS., Wasting syndrome: oral oxandrolone re-released in U.S., AIDS Treat
News 1995 Dec 22;(no 237):3-4


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