Good HGH Article
hormones have generated more excitement and hype in recent years than HGH. From
reports of incredible fat loss to tales of increases in lean muscle that defies
genetics, HGH has been touted as one of the panaceas of all bodybuilding woes.
Depending on which statistics you trust, reports of as many as 80% of
professional athletes have used or are using HGH as a supplement to their
of this guide is to give you a good working knowledge of HGH and how to
intelligently use it. While this is not intended to cover every conceivable
nuance of HGH use, it should provide you with a solid background to create your
cycle around. So lets take a look at this hormone called HGH.
WHAT EXACTLY IS HGH?
Human Growth Hormone (somatotropin – also referred to as rHGH, HGH, or GH) is
created by the pituitary gland, the primary form consisting of a 191 amino acid
chain. When we are young, HGH is in big part responsible for the proper growth
of bones, muscle, and other tissues. To little of this hormone and we remain
dwarfs … too much and we become giants and/or suffer from abnormal growth
deformities. As we become adults, HGH is responsible for keeping muscles from
wasting away, supports healthy immune system response, regulates aspects of our
metabolic function dealing with increased fat metabolism and healthy body
composition in later life, and maintains and repairs our skin and other
Our levels of HGH peak while we are adolescents and then begin to drop off
sharply beginning in our 30’s. By our 60’s, our daily HGH secretion can be as
little as 10% of what it was during our youth. Many of the markers of aging are
affected by this decrease in HGH. Some of the results of this are:
· Increase in fat.
· Decrease in muscle and lean body structures.
· Decreased skin texture resulting in a less youthful appearance.
· Decreased bone density, onset of osteoporosis.
· Decreased brain function, loss of intellect with aging.
· Decreased sex drive.
· Decrease in overall physical and mental well being.
· Increase in sleep disorders, lower quality of sleep.
· Depression and fatigue.
The addition of supplemental HGH beginning in the later 30’s can reverse or
improve these symptoms in the majority of people attempting therapy. This is
why you will often hear references with respect to HGH as “the fountain of
youth” and other similar terms. It can present a better quality of life for
those aging as well as provide some great benefits for bodybuilders.
For bodybuilders, HGH (and the IGF-1 that is a result of its use) is the only
substance that can actually initiate hyperplasia, which in the interest of our
use in bodybuilding equates to new muscle cells. While use of anabolic steroids
can cause hypertrophy (the enlargement of existing muscle cells), steroids do
not offer the ability to recruit and mature more muscle cells. HGH can. HGH
also increases protein synthesis, which can be responsible for hypertrophy. HGH
also strengthens and heals connective tissues, cartilage, and tendons. These
uses are what make it so attractive to athletes in all sports, and in
bodybuilding in particular.
HOW IS HGH RELEASED IN YOUR BODY?
HGH is secreted from the pituitary in a pulsatile fashion, generally following
a circadian rhythm. A number of stimuli can initiate an HGH secretion, the most
powerful being short duration, high intensity exercise and sleep. During the
first few hours of sleep (deep sleep stages), Somatostatin is turned off and
GHRH is turned on, resulting in HGH bursts.
HGH secretion is stimulated by Growth Hormone Releasing Hormone (GHRH) which is
produced by the hypothalamus. HGH, and IGF-1 create a negative feedback loop,
meaning when their levels are high, it blunts release of GHRH, which in turn
blunts the release of more HGH.
Somatostatin (SS), secreted by the hypothalamus as well as other tissues
inhibits the secretion of HGH Somatostatin in response to GHRH and to other
stimulatory factors such as low blood glucose concentration. High levels of
IGF-1 also stimulate Somatostatin secretion.
Ghrelin is a peptide hormone secreted from the stomach. Ghrelin binds to
receptors on somatotrophs and potently stimulates secretion of growth hormone.
Ghrelin, as the stimulator for the growth hormone secretagogue receptor,
potently stimulates secretion of growth hormone. The ghrelin signal is
integrated with that of growth hormone releasing hormone and somatostatin to
control the timing and magnitude of growth hormone secretion.
Once HGH is released, it is very short lived. It is generally metabolized and
gone within a half-hour. During this half-hour, it travels to the liver and
other tissues and induces them to secrete a polypeptide hormone called
Insulin-like Growth Factor One (IGF-1).
HOW DOES HGH DO ITS WORK?
As mentioned above, HGH is short lived, but during its short half-hour or so
activity per burst from the pituitary, it exerts itself through direct and
Its direct effects are the result of the HGH binding its receptor on target
cells. Fat cells (adipocytes) as well as myocytes (muscle cells) have HGH
receptors. On fat cells, HGH stimulates them to break down triglyceride and
suppresses the fat cells ability to uptake circulating lipids.
Its indirect effects are in the process we described in the section above. When
HGH travels to the liver, the result in its pass through the liver is the
secretion of IGF-1. When this IGF-1 is secreted, it stimulates proliferation of
chondrocytes (cartilage cells), which result in bone growth. It also plays a
part in stimulating both the proliferation and differentiation of myoblasts
(the precursor to skeletal muscle fibers). IGF-1 also stimulates amino acid
uptake and protein synthesis in muscle and other tissues.
HGH stimulates protein anabolism in many tissues. This reflects increased
protein synthesis, decreased oxidation of proteins, and increased amino acid
uptake. As mentioned above, HGH enhances fat utilization by stimulating
triglyceride breakdown and oxidation in fat cells (adipocytes).
HGH can affect the function of other hormones. HGH can suppress the abilities
of insulin to stimulate the uptake of glucose in tissues and enhance glucose
synthesis in the liver, though administering HGH actually stimulates insulin
secretion and can create a state of hyperinsulinemia. This combination can lead
to decreased insulin sensitivity, which in turn can lead to hyperglycemia. HGH
can also have a slight inhibitory effect on the thyroid, though this varies
greatly from individual to individual. We’ll discuss more on how to deal with
these potential effects later in this guide.
Okay, so we have a hormone that can assist with maintenance and healing of most
of the body’s systems, can create new cartilage, bone, and muscle cells, can
assist with protein uptake, decrease the oxidation of proteins, and can
accelerate the rate at which fat is utilized. This paints the picture of the
excitement that follows HGH. So how do we utilize this to our advantage? Let’s
look at what is involved in exogenous HGH use.
HOW DO I INCREASE MY LEVELS OF HGH?
To state it simply, we need to inject exogenous HGH. There are a few methods to
increase your own production of HGH, but for the most part these aren’t going
to give us the increase necessary to promote the benefits mentioned above in
their full measure.
By adding several grams of Arginine and Glutamine to our daily supplement
program, we can increase our levels of HGH. This increase equates for a very
small amount though, so unless are very young or we are only in need of a
modest jump in production, this is not an optimal way to proceed.
As mentioned at the beginning of our guide, intense short duration exercise
will also induce a sizable HGH release.
Another possibility is to inject GHRH. This peptide is available from research
companies and when injected at doses of 100mcgs per day, sub-q it does seem to
show promise in increasing levels of HGH. At this stage, there isn’t a real
cost advantage to this over rHGH, so unless we are trying to promote some of
the other forms of HGH in addition to the primary form, there is no clear
advantage to this course of action.
What we are left with is acquiring and injecting recumbent Human Growth
Hormone. The remainder of our guide will concentrate on its use.
INJECTIBLE HGH AND ITS USE
HGH only comes in the form of a lyophilized powder. Any other form that you see
advertised or run across is NOT true HGH. The only way to administer true HGH
is by sub-q or intramuscular injection.
HGH is somewhat fragile by nature, and it needs to be protected from light and
heat. HGH should be stored between 36 and 46 degrees Fahrenheit at all times
both before and after its reconstitution.
There are a couple of American brands of HGH that can survive in normal room
temperature for a reasonable amount of time BEFORE reconstitution (Genotropin –
3 months, Saizen – until expiration) , but for the most part it is better safe
than sorry. All brands of HGH should be refrigerated after being reconstituted,
and all brands should be protected from light at all times.
RECONSTITUTING AND MEASURING YOUR HGH
So you now have a vial HGH in the form of lyophilized powder. The amount of
this powder should be indicated on the vial somewhere. It will either be stated
in Units (IU’s) or in Milligrams (mg). If it is stated in milligrams, the
conversion is most commonly stated as 1mg = ~3IU’s (its really more precisely
1mg=2.7IU). We will use this 1mg = 3IU’s for our guide since this is the
standard most commonly referenced by manufacturers.
What we need to do with this lyophilized powder is add either some
Bacteriostatic water (BW), Sterile Water, or even liquid vitamin B12 to
reconstitute it and make it ready to inject.
What we choose to reconstitute it with should depend on how rapidly we use the
GH. Bacteriostatic water is basically sterile water with 0.9% Benzyl Alcohol
added, and this Alcohol keeps anything from growing in the water, thus making
it safe for injection for the longest amount of time, up to three weeks. If the
amount of GH in our vial is enough to last for a few weeks at our desired daily
dosage, BW is the wisest choice. For the common use for bodybuilding (2-5 IU’s
a day) and the more commonly used vial size (10 IU’s), it isn’t really as
critical which of the above listed dilutents are used……the vial will be
used up long before bacteria or anything begins to grow in our reconstituted
HGH. It is really personal preference outside of the considerations listed
1.) Take a alcohol swab and swab the stopper of both your HGH vial and the vial
of the dilutent (BW, sterile water, B12).
2.) Take a 3cc syringe with a 23 or 25 gauge needle (1″ or 1.5″) and
draw up and amount of your preferred dilutent. The amount isn’t critical, other
than making sure you know exactly how much you have used. The best rule of
thumb is choose an amount that will make measuring the final product easy
example- 1ml(cc) per 10 IU vial of HGH would mean each 10 mark on a U100 slin
syringe would equal 1 IU of HGH
2ml(cc) added to a 10 IU vial of HGH would mean that the 20 mark on a U100
syringe would equal 1 IU of HGH
3ml(cc) added to a 10 IU vial of HGH would mean that the 30 mark on a U100
syringe would equal 1 IU of HGH
3.) Take this syringe with the dilutent and push it into the vial of
lyophilized powder, angling so that the needle touches the side of the vial,
and avoiding shooting the dilutent directly on the lyophilized powder. Make it
run slowly down the side of the vial (don’t let it forcefully rush in).
4.) After all of the dilutent has been added to the HGH vial, gentling swirl
(do NOT agitate or violently shake the vial) until the lyophilized powder has
dissolved and you are left with a clear liquid. The HGH is now ready for use.
Store your now reconstituted HGH in the refrigerator. If you used BW to
reconstitute it will be good for three weeks. If you used sterile water, it
will be good for about 5 days.
After you have successfully reconstituted your HGH, now you need to know how to
measure the desired amount out for injection. You will want to use a U100
insulin syringe to draw out and inject your HGH.
Here is the way to figure out how much to draw out. Since you know the amount
of IU’s in your HGH vial, and you also know how much water you have diluted it
with, we just divide this out as follows:
You will need to know the following to be successful -
1ml = 1cc = 100 IU’s
So we take our number of IU’s of HGH from the label of the dry lyophilized
powder (most commonly 10 IU’s for all of us Jintropin users), and we divide
that into the amount of dilutent we used.
example- We used 1cc(ml) of water. We have a 10 IU vial of HGH.
From our formula above we know that 1cc = 100 IU’s, so we have 100 IU’s of
We now divide the 100 IU’s (the amount of our water) by 10 IU’s (the amount of
100 IU / 10 IU = 10
This 10 will perfectly correspond with the markings on a U100 insulin syringe.
In our example every 10 mark on our syringe will equal 1 IU of HGH. Want to
draw out 2 IU’s of GH? ….draw out to the 20 mark on the syringe.
This is about all there is to it. So to recap, just keep straight:
1.) How much actual HGH you are dealing with (read from the vial)
2.) How much water (dilutent) you are using to add to the actual HGH.
3.) Divide the amount of water in units by the amount of GH in units.
4.) This result will equal the measurement on your U100 Insulin syringe per
unit of GH.
5.) multiply the number you get it step 4 by how many units you want to inject.
This is the number to draw to on your syringe.
Now that we know what HGH is and how to reconstitute and measure it, lets look
at some strategies for using it to our best advantage
STRATEGIES FOR USING HGH
There are many different approaches to taking HGH. The right approach for your
particular situation will depend on your goals. For many, HGH is a general purpose
supplement to help maintain low bodyfat percentages and reasonable levels of
lean body mass. For others who have reached their genetic potential for growth,
HGH is a supplement that can assist in continued growth beyond what mother
nature gave you to work with. For yet others, it is a supplement that is used
for general health and healing of injuries. Let’s look at each of these uses
with respect to a reasonable HGH program.
To begin with, it should be stated that for the vast majority of HGH users, results
are not rapid and earthshaking in nature. If your idea of using HGH is to get
ripped in a few weeks, gaining 20 pounds of muscle in a matter of a month or
two, or being miraculously healed in a matter of a few injections … you are
likely in for a BIG disappointment. HGH does some pretty incredible things, but
it HAS to be viewed as a long-term endeavor. A reasonable length HGH cycle
would be 20-30 weeks in length. While you will always be able to find the one
or two individuals who will make great strides in a short amount of time, the
majority need to be dedicated to its use for the long haul for it to be a
As mentioned in our introduction to HGH, one of the major roles it plays in
growth is by its passing through the liver, which in turn secretes IGF-1. This
process is cumulative in nature, and it will take some time for your exogenous
HGH use to bring your IGF-1 levels to create an environment conducive to
optimal growth. While it is true that HGH begins shuttling nutrients to your muscles,
and begins mobilizing fat from the first injection, these behind the scenes
benefits will only be VISIBLE several weeks (up to 12) down the road.
For anti-aging, general health & healing, fat mobilization:
For these purposes, a dose of 2-3 IU’s per day will be sufficient for the
majority. A dose of 1.5 to 2.0 IU’s is considered to be a full replacement dose
for those in their middle-age and beyond.
For gaining lean muscle and substantially improving body composition:
For this purpose a dose of 4-8 IU’s per day will be necessary. Most people will
respond very well at a dose of 4-5 IU’s per day.
For maximum benefit in this regard, the addition of Testosterone, Insulin, and
low-dose T3 would be something to seriously consider.
Regardless of your goal, as a general rule the best way to begin your HGH
program is to start with a low dose and ease your body into the higher doses.
This will allow you to avoid or at least minimize many of the more common sides
of HGH such as bloating and joint pain & swelling. Most people can tolerate
up to approximately 2 IU’s with few sides, so that would be a good place to
For many using this as a general health supplement, that is as high as you will
need to go. For others this will be only the start. Above 2.5 – 3 IU’s, I would
definitely suggest that your split your injections into two per day instead of
one unless it is just not feasible to do so.
Here is what a good ramp up program would look like:
Weeks 1-4 = HGH 2 IU’s one injection
Week 5 = HGH 2.5 IU’s one injection
Week 6 = HGH 3.0 IU’s split into two injections of 1.5 IU’s each
Week 7 = HGH 3.5 IU’s split into two injections of 1.75 IU’s each
And so forth until you reach your desired dose.
If at any point in this progression you begin to have unbearable bloating or
joint pain, drop the dose by 25% and hold it at this lower dosage for a couple
of weeks. If the sides subside, begin your progression back up toward your
desired level. If the sides remain, lower your dose again and hold it at the
lower level for two weeks before beginning the upward progression. This method
will keep your HGH experience a good one and side free for the most part.
For a normal cycle of 5-8 months in length, injecting once or twice a day, 7
days a week should be fine. While there are studies that suggest that the
suppression from exogenous HGH is short lived (about 4 hours from injection),
there are no large-scale studies to indicate safety of everyday injections in
long-term use. There are studies by anti-aging groups demonstrating that a day
or two off per week is adequate to protect the pituitary and its triggers over
long cycles. If your use of HGH becomes more a lifestyle than a single cycle, I
would consider running it 5 on/2 off, or 6 on/ 1 off until such time as we have
reliable data demonstrating long-term safety sans any degradation of your own
output or the triggers initiating that output.
Another option would be to run your HGH cycle everyday for the first two months
to get your IGF-1 levels elevated quickly and to a level to assist you in an
anabolic way, then drop back to 5 days a week.
As described above, the body produces HGH is a pulsatile fashion throughout the
day with the heaviest pulses occurring approximately 2-3 hours after going to
bed as you fall into a deep sleep. Injectible HGH is completely absorbed and
put to use within approximately 3 hours. The strategy with respect to timing
depends somewhat on our age and the other elements of our cycle. As you will
see below, there is no single best strategy … it depends a lot on your
For those that are between their late 20’s and early 50’s, there is still a
reasonable chance that your own endogenous production of HGH is still at a
reasonable level. The best time to take and injection, this being the case,
would be early morning …. After your body’s own release of HGH in the night. If
you get up to go to the bathroom in the early morning, this is probably the
perfect time to take a couple of units of HGH. This will be the least disruptive
time to take an injection of HGH. The second best time would be first thing in
the morning when you wake up.
If you are splitting your doses, two times of the day when your cortisol levels
are at peak are when you wake up and in the early afternoon. Another good
strategy is to take your HGH injections at these times. Cortisol is very
catabolic by nature and a well -timed HGH injection can go a long way toward
blunting this effect.
If you are in your late 50’s or beyond, or if for some reason you have a
condition that has rendered your pituitary incapable of a normal release of
HGH, a great time to take HGH is right before bed. This allows you to closely
mimic the natural pattern that would occur if your pituitary were functioning
properly. For the rest of us, taking your HGH right before bed is going to end
up creating a negative feedback loop, robbing you of your body’s own nightly
pulse of HGH.
Yet another strategy should be considered if you are using insulin with your
HGH. Insulin should be used immediately post workout. HGH and insulin do some
great things together – they shuttle nutrients in a very complimentary way with
each other, and the combination of HGH and Insulin create the best environment
for IGF-1 production. If you are using insulin immediately post workout, this
would be a great time to take a couple of units of HGH.
SIDE EFFECTS – HOW TO MANAGE THEM
While HGH for the most part is well tolerated, there are some side effects that
can occur. The biggest and most common side effect is bloating and joint pain.
The chances of getting these can be minimized or even eliminated by utilizing
the ramp up method discussed above.
If you are younger than your late 20’s, it would be very wise to enter an HGH
cycle under the guidance of an MD, who can monitor and confirm whether your
growth plates have fused. While abnormal bone growth with HGH use is not
common, if used at the wrong point in your body’s development, it could cause
If you have a history of cancer or other tumors (at any age), it would be wise
to get a complete checkup and be monitored by an MD to make sure that there are
no active tumors before your HGH cycle. While HGH (and IGF-1) won’t cause
cancer or tumors, they can create an environment that can allow already
existing, active tumors to grow at an accelerated rate.
Beyond this, there really isn’t anything specific that you would HAVE to take
with HGH. There are supplements that you could take for specific conditions
that are possible with HGH use. The way people react to HGH is a pretty
individual thing. Some people get very little suppression of any kind, others
don’t see any gains from adding HGH because of significant enough suppression
of one kind or another. Here’s a general rundown of a few of the bigger ones.
For the slight thyroid suppression that is possible:
conservative – take nothing
moderate – t-100x, bladderwrack, coleus forskolin, selinium, zinc, chromium,
aggressive – T3 at a dose of 12.5 – 25 mcgs per day
For the insulin resistance that is possible:
conservative – 300mg of Alpha Lipoic Acid and 200 – 300mcgs of Chromium
moderate – 15mg of Actos – a prescription med to increase insulin sensitivity,
Glucophage or Metformin to dispose of excess glucose and increase uptake in
aggressive – add a few IU’s of insulin to your HGH cycle
For healthy test levels to best utilize HGH:
conservative – do nothing
moderate – use Tongkat or Tribulus
aggressive – add 200-300 milligrams (or more) of testosterone weekly to your
For protection against prostate growth:
conservative – do nothing
moderate – use Saw Palmetto (approx 2000mg)
aggressive – use Proscar or equivalent
For those that have a problem with breast tissue growth while on HGH
For those that suffer from this, there is a difference of opinion as to the
cause. In the presence of adequate estrogen, HGH can prompt growth or breast
tissue. Others theorize that HGH can raise prolactin levels, which can prompt
The current consensus seems to be that the best approach for those with this
problem is twofold – Take 200mg of B6 (or Bromo if B6 is not sufficient) and
also use 20-40mg of Tamoxifen (Nolva) to control this.
Once again, I wouldn’t say that all of these are necessary for everyone. I would
these supplements as needed to correct whatever conditions that arise with your
HGH use. As stated above, reaction to HGH (and just about anything else we use)
is very individual.
Hopefully this guide has given you a better understanding of HGH and what it
can do for you. HGH, especially when used in conjunction with an AAS cycle,
will produce some high-quality, lean mass gains. It can also be used in
conjunction with IGF-1 and insulin, which will be the topic of our comparative
guide. Happy growing!!