In Regard IFG-1! All questions answered!
Here is all
the information requested the past week in regards to IGF-1! this should clear
the air and answer
alot of questions for you all! enjoy! wyldeone. IGF stands for insulin-like
growth factor. It is a natural
substance that is produced in the human body and is at its highest natural
levels during puberty. During
puberty IGF is the most responsible for the natural muscle growth that occurs
during these few years.
There are many different things that IGF does in the human body; I will only
mention the points that would
be important for physical enhancement. Among the effects the most positive are
increased amino acid
transport to cells, increased glucose transport, increased protein synthesis,
degradation, and increased RNA synthesis.
is active it behaves differently in different types of tissues. In muscle cells
associated cell components are stimulated. Protein synthesis is increased along
with amino acid
absorption. As a source of energy, IGF mobilizes fat for use as energy in
adipose tissue. In lean tissue,
IGF prevents insulin from transporting glucose across cell membranes. As a
result the cells have to switch
to burning off fat as a source of energy.
IGF also mimic’s insulin in the human body. It makes muscles more sensitive to
insulin’s effects, so if you
are a person that currently uses insulin you can lower your dosage by a decent
margin to achieve the same
effects, and as mentioned IGF will keep the insulin from making you fat.
Perhaps the most interesting and potent effect IGF has on the human body is its
ability to cause hyperplasia,
which is an actual splitting of cells. Hypertrophy is what occurs during weight
training and steroid use, it
is simply an increase in the size of muscle cells. See, after puberty you have
a set number of muscle
cells, and all you are able to do is increase the size of these muscle cells,
you don’t actually gain more.
But, with IGF use you are able to cause this hyperplasia which actually
increases the number of
muscle cells present in the tissue, and through weight training and steroid
usage you are able to mature
these new cells, in other words make them grow and become stronger. So in a way
IGF can actually change
your genetic capabilities in terms of muscle tissue and cell count. IGF
proliferates and differentiates
the number of types of cells present. At a genetic level it has the potential
to alter an individuals
capacity to build superior muscle density and size.
There is a lot of talk about the similarity between IGF and growth hormone. The
most often asked question
is simply which is more effective. GH doesn’t directly cause your muscles to
grow, it works very indirectly
by increasing protein synthesis capabilities, increasing the amount of insulin
a person can use
effectively, and increasing the amount of anabolic steroids a person can use
effectively. GH also
indirectly causes muscle growth by stimulating the release of IGF when it (the
GH) is destroyed in the
human body. So one way you could look at it as GH being a precursor to IGF. So
to put it simple IGF is
more effective at directly causing muscle growth and density increases. IGF is
also much more cost
IGF can also be effectively used by itself and gains will still be easily
noticeable. With growth hormone
you need to use high amounts of anabolics and often insulin to see any gains at
all, this is not the case
with IGF. IGF can be used by itself and is often used by bodybuilders who
bridge between cycles, during this
bridge is a good time to use IGF since it has no effect on natural testosterone
production so it will
therefore allow you to return to normal in terms of hormone levels. A stack of
IGF, PGF2a, HCG, and clomid
would be a good bridge stack and would allow your body to return to normal and
still allow you to retain and
make new gains.
IGF is a research drug, it hasn’t been approved by the FDA for use as a
pharmaceutical and it is currently
being researched for nerve tissue repair, possible burn victims, and also as a
possible aid in muscle
wasting for AIDS patients. There are many different analogs of IGF available,
instead of mentioning them
all, I will simply mention the two most common and the most effective. Regular
recombinant IGF is one of the
two, it is also the more expensive and the least effective. Regular IGF only
has a half-life of about
10-20 minutes in the human body and is quickly destroyed, it can be combined
with certain binding
proteins to extend the half-life, but it is not a very simple procedure and
there is a more effective and
less expensive version available. The most effective form of IGF is Long R3
IGF-1, it has been chemically
altered and has had amino acid changes which cause it to avoid binding to
proteins in the human body and
allow it to have a much longer half life, around 20-30 hours. “Long R3
IGF-1 is an 83 amino acid analog of
IGF-1 comprising the complete human IGF-1 sequence with the substition of an
Arg(R) for the Glu(E) at
position three, hence R3, and a 13 amino acid extension peptide at the N
terminus. This analog of
IGF-1 has been produced with the purpose of increasing the biological activity
of the IGF peptide.”
“Long R3 IGF-1 is signifacantly more potent than IGF-1. The enhanced
potency is due to the decreased
binding of Long R3 IGF-1 to all known IGF binding proteins. These binding
proteins normally inhibit the
biological actions of IGF’s.”
It is also not as expensive since a media grade version is available which is
bodybuilding use. There is also a receptor grade available but it is VERY
expensive and the only
noticeable difference between the two would only be able to be noticed in a
laboratory setting. The price
on the black market for Long R3 IGF-1 can be seen anywhere from $300-$500 per
milligram depending on the
source, be wary of black market ******s of any IGF since it is a VERY difficult
item to obtain. As
mentioned IGF is a research product and is only available from a few
laboratories in the world and is
only available to research companies and biotechnology institutions. For the
rest of this article when I say
IGF I am now referring to Long R3 IGF-1 for simplicity sake.
Any form of IGF is ONLY supplied in a lyphosized form, which means a dry powder
state. NEVER PUCHASE
PRE-DILUTED LIQUID IGF!!!! There is no such product made anywhere in the world
and even if there were real
IGF ever present in the vial it would all be dead by the time you receive it.
IGF is a very delicate
peptide and must be diluted by yourself, where you have access to a
refrigerator and freezer. There has
also been a lot of talk by certain sources claiming to have IGF made by the Eli
Lilly company, to clear
things up Lilly is a pharmaceutical company and as stated IGF is a research
drug and has not yet been
approved, Lilly does not and never has manufactured research drugs for retail
The dilutents you will need for the IGF are a weak concentration of
hydrochloric acid and a sterile
buffer(sterile water or bacteriostatic water) the procedure for diluting the
IGF is not very difficult,
the dilutents can be obtained from most local chemical suppliers and a good
source of IGF would also be able
to supply the necessary dilutents.
The most effective length for a cycle of IGF is 50 days on and 20-40 days off.
The most controversy
surrounding Long R3 IGF-1 is the effective dosage. The most used dosages range
between 20mcg/day to
120+mcg/day. IGF is only available by the milligram, one mg will give you a 50
day cycle at 20mcg/day, 2mg
will give you a 50 day cycle at 40mcg/day, 3mg will give you a 50 day cycle at
60mcg/day, 4mg will give
you a 50 day cycle at 80mcg/day and so on. The dosage issue mainly revolves
around how much money you have
to spend, plenty of people use the minimum dosage of 20mcg/day and are happy
with the results, and in fact
several top bodybuilders use the 20mcg/day dosage and are pleased with the
results. IGF is most effective
when administered subcutaneously and injected once or twice daily at your
current dosage. The best time for
injections is either in the morning and/or immediately after weight training.
Another frequently asked question of IGF refers to the real world results, in
terms of pure weight gain don’t
expect to gain 5 lbs. a week like you may off of anadrol or a similar steroid.
The only weight you will
gain from IGF use is pure lean muscle tissue, with steroids most of the weight
gained is water weight.
With an effective dosage you can expect to gain 1-2 lbs of new lean muscle
tissue every 2-3 weeks and
these effects can be increased with the use of testosterone, anabolic steroids,
and insulin use.
Increased vascularity is also very common, people report seeing veins appear
where they never have
before. And yet another effect reported is the ability to stay lean while
bulking with heavy dosages of
steroids and TONS of food while on an IGF cycle, this is perhaps the most
pleasing effect. Increased pumps
are also noticeable almost immediately, the pumps can almost become painful,
pumps are even noticeable when
Overall, IGF is a very exciting drug due to its ability to alter ones genetic
capabilities. If you can
find a trustworthy source and you use it correctly it can be a VERY useful tool
in your bodybuilding drug
Long™R3IGF-I is an analog of human IGF-I.
· It is a superior alternative to insulin in
· It increases protein production by cells in culture
· It increases cell viability by inhibiting apoptosis.
· It has a longer half-life in cell culture than
· It is readily available.
· There is secure and ample manufacturing capacity at
· No animal- or human- derived material is used in the
manufacture or storage of Long™R3IGF-I.
· Long™R3IGF-I is already being used in the
manufacture of three (3) biopharmaceuticals approved
by FDA and EMEA.
Frequently Asked Questions
What cell types will respond to Long™R3IGF-I?
All cells that have a Type I IGF receptor will potentially respond. Most
commercially used cells
including CHO, fibroblasts and hybridomas have a type I IGF receptor. All cells
which respond to
pharmacological concentrations of insulin (>1mg/liter) will respond to
Is storage of the stock solution at 4°C acceptable?
How long is the stock solution stable for under these storage conditions?
Liquid stability data shows that Long™R3IGF-I is stable for 3 years (-20°C to
37°C). Therefore, the
stock solution should be stable at 4°C for 3 years.
What type of preparation is available?
Liquid formulation, preferable for GMP production. Freeze dried preparation.
Is Long™R3IGF-I stable?
Re-test date for freeze-dried peptide is 3 years. Liquid formulation stability
studies have recently
been completed. It is stable for 3 years (-20°C to +37°C). We have data
indicating stability in media at
4°C for 1 year.
Here is an article written by a self-experimenter.
December 15, 2000
Answer: What a perfect question! You actually have talked to just the right
person. I have a business
associate that worked for the company that produces this in Australia. Several
years ago, I ordered 10mg
of Long R3 IGF-1 and used it for several months. What I found out was truly
Before I tell you about my results, let me tell you that if you are going to
use IGF-1 then make sure it
is the Long R3 version! Let me explain. Regular IGF-1 like what is produced in
your body is transported
around connected to binding proteins. There are quite a few of these and their
main purpose is to grab ahold
of the IGF-1 peptide and keep it from being quickly degraded. Without these
binding proteins, all of the
IGF-1 would be metabolized in the body within a few minutes. The problem (at
least it seems like a problem
but might actually be a good thing) is that these binding proteins basically
prevent the IGF-1 from
performing its function. As long as IGF-1 is attached to the binding protein it
cannot do the cool stuff
that it wants to do. Regular IGF-1 must be released from its binding protein in
order to accomplish its
mission. Part of the problem is that much of the IGF-1 is degraded before it is
released (seems like much is
wasted doesn’t it?)
With Long R3 IGF-1 this problem doesn’t exist. Understand that the Long R3
version does not bind to
the various binding proteins. It is free to move throughout your body and
immediately start doing all
the cool stuff that it wants to do. Again, understand that the Long R3 version
is several orders of
magnitude stronger than regular IGF-1.
If you would happen to use regular IGF-1, you would need several milligrams per
day in order to get the
desired effect. With the Long R3 version, you need only microgram quantities.
Long R3 is also inherently
MUCH cheaper to produce. What I am saying is that for the average person,
regular IGF-1 is not practical-it
is too expensive and you need to use too much. With Long R3 IGF-1, the price to
results ratio is pretty
Something else I want to explain is how I went about preparing it for injection
into my body.
Unfortunately, this is not easy and the average person will have a hard time
doing it. At the time, I worked
in a sophisticated lab which had all of the necessary equipment. I ordered 10mg
of Long R3 IGF-1 and it came
in a single flip-top vial. 10mg might not seem like much but believe me, when
it comes to Long R3 IGF-1,
it is a ton! Some people might say to just add saline to the vial, keep it in
the fridge and inject it when
necessary. However, this will not work well because the IGF-1 is not highly
stable and will degrade in an
aqueous environment. 10mg was enough for many months and I needed a way that
would allow the IGF-1 to
remain potent during this entire time. I did my research and developed my
method. I ordered what is
known as microvials and sterilized them. I then diluted the IGF-1 with sterile
water and added just a
tad of acid to increase stability. Although it took quite a while, I then used
a micropipette and
alliquotted an amount of solution that contained 50mcg into one of my
microvials. I closed the microvial and
then froze it in a deep freezer. When I was ready to inject, I took out one or
more of my microvials,
thawed it out, combined it with saline and injected it.
When I first started taking Long R3 IGF-1, I used 50mcg every other day.
Amazingly, within days, I
started noticing some effects in my body. I felt super hungry all of the time
and just felt “anabolic”. I
can’t describe this feeling except to say that it was very similar to being on
anabolic steroids (I wasn’t
on at the time). Within one month, I gained almost 17 pounds of fairly lean
mass! After the first month,
something happened though and I noticed that it didn’t seem to be working that
well. I upped the dosage
several times over the next month to keep up the desired effects. On the third
month, I was using
several hundred micrograms per day but wasn’t noticing any further gains. All
in all, I gained about 20
pounds of pretty solid mass!
Please notice that almost all of my gains were within the first month of taking
the Long R3 IGF-1. After
this first month, my gains slowed down considerably and eventually stopped
altogether even though I was
taking high dosages. Why did this happen?
From all of my research, I suppose one of two things might have happened to
prevent me from making further
gains. What I truly suspect is that the Long R3 IGF-1 downregulated the amount
of binding proteins being
produced by my body (research confirms this). When I first started to inject
the IGF-1, I was supplementing
my own body’s IGF-1. I not only had my own IGF-1 working throughout the day but
I had the potent surges
of Long R3 IGF-1 that I would inject. Over time though, the binding proteins
were downregulated. Of
course my body continued to produce some (albeit less) IGF-1, however, because
there were very little or no
binding proteins it was quickly degraded. From what I can tell, I was in a
state where 95% of the day my
body did not have the benefits of IGF-1. Basically, it got what it got when I
injected the Long R3 version.
The other possibility is that I built up antibodies to the Long R3 IGF-1 which
basically sought out and
destroyed what I injected. Although possible, I don’t believe this actually
happened because it is not
supported by research. I have seen no evidence which suggests that Long R3
IGF-1 causes antibody
To fix the above problem, one would have to cycle the Long R3 IGF-1. The best
thing would probably be to
take it every other month. This would allow your own body’s IGF-1 and binding
proteins to return to normal.
Overall, I had a good experience with Long R3 IGF-1. The results were different
than with steroids. I have
noticed that steroids cause preferential growth of certain muscles, especially
those that are stressed
(as in lifting). The IGF-1 though seemed to cause my entire body to get a
little thicker. I guess IGF-1 is
less compensatory in nature and exerts a more whole-body anabolicity.
Would I recommend IGF-1? To the right person who is very careful and knows what
he’s doing and has a good
background in the sciences and has access to a good lab, YES! However, you can
tell that I have listed
many prerequisites to using it. For the average Joe, I believe is is just too
complicated to be safe.